Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed

Regulator ID	Locus tag (Gene)	Related T6SS	Regulator type	Regulatory pathway	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID	Target (Regulation)
REG0007	Y880_04683 (pnp)	T6SS01211 ; T6SS01212 ; T6SS01213	protein	RsmA regulatory pathway	Pseudomonas aeruginosa PAK	chromosome (NZ_CP020659)	4637120..4639225 (-)	489185761	PA0527.1 (RsmY) (↑); PA3621.1 (RsmZ) (↑)
REG0019	PC1_3721 (Hfq)	T6SS01001	protein	QS regulatory pathway	Pectobacterium carotovorum subsp. carotovorum PC1	chromosome (CP001657)	4199890..4200189 (-)	251756660	hcp expression (↓)
REG0299	VCA1552_RS00505 (hfq)	T6SS01112	protein	QS regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	92673..92936 (+)	446974616	VCA1552_00351 (HapR) (↑)
REG0344	BN49_RS26620 (hfq)	T6SS01214	protein	QS regulatory pathway	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	5173711..5174019 (-)	488974767	TssB transcription (↓)
REG0367	H78_RS02920 (Hfq)	-	protein	QS regulatory pathway	Pseudomonas protegens strain H78	chromosome (NZ_CP013184)	662937..663197 (+)	495196588	T6SS transcription level (↓)
REG0058	PA2976 (RNase E)	T6SS00003	protein	Unknown	Pseudomonas aeruginosa PAO1	chromosome (NC_002516)	3332881..3336054 (+)	15598172	PA0077 (icmF1) expression (↑)